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[Thalidomide used by patients with erythema nodosum leprosum].
- Source :
-
Revista da Sociedade Brasileira de Medicina Tropical [Rev Soc Bras Med Trop] 2010 Mar-Apr; Vol. 43 (2), pp. 201-4. - Publication Year :
- 2010
-
Abstract
- Introduction: Thalidomide is a drug currently used in Brazil for treating erythema nodosum leprosum.<br />Methods: This was a prospective study to follow up clinical evolution, record adverse events and determine plasma thalidomide levels from a dose of 100 mg/day, among 20 patients with clinical manifestations of erythema nodosum leprosum, divided into two groups: during or after leprosy multidrug therapy.<br />Results: No significant differences between the groups were seen during the study, either in relation to favorable clinical evolution among the patients (70% and 90%), or in relation to the adverse events recorded, which were dizziness and somnolence. The plasma thalidomide levels on D7 and D14 were 0.82 + or - 0.4 microg/ml and 0.79 + or - 0.3 microg/ml in group 1 and 0.82 + or - 0.4 and 1.55 + or - 1.0 in group 2, respectively.<br />Conclusions: In this sample, the multidrug therapy had no effect on the clinical evolution, incidence of adverse events and plasma thalidomide levels.
- Subjects :
- Adolescent
Adult
Erythema Nodosum blood
Female
Humans
Leprostatic Agents adverse effects
Leprostatic Agents blood
Leprosy, Lepromatous blood
Male
Middle Aged
Prospective Studies
Thalidomide adverse effects
Thalidomide blood
Young Adult
Erythema Nodosum drug therapy
Leprostatic Agents therapeutic use
Leprosy, Lepromatous drug therapy
Thalidomide therapeutic use
Subjects
Details
- Language :
- Portuguese
- ISSN :
- 1678-9849
- Volume :
- 43
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Revista da Sociedade Brasileira de Medicina Tropical
- Publication Type :
- Academic Journal
- Accession number :
- 20464154
- Full Text :
- https://doi.org/10.1590/s0037-86822010000200019