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[Thalidomide used by patients with erythema nodosum leprosum].

Authors :
Valente Mdo S
Vieira JL
Source :
Revista da Sociedade Brasileira de Medicina Tropical [Rev Soc Bras Med Trop] 2010 Mar-Apr; Vol. 43 (2), pp. 201-4.
Publication Year :
2010

Abstract

Introduction: Thalidomide is a drug currently used in Brazil for treating erythema nodosum leprosum.<br />Methods: This was a prospective study to follow up clinical evolution, record adverse events and determine plasma thalidomide levels from a dose of 100 mg/day, among 20 patients with clinical manifestations of erythema nodosum leprosum, divided into two groups: during or after leprosy multidrug therapy.<br />Results: No significant differences between the groups were seen during the study, either in relation to favorable clinical evolution among the patients (70% and 90%), or in relation to the adverse events recorded, which were dizziness and somnolence. The plasma thalidomide levels on D7 and D14 were 0.82 + or - 0.4 microg/ml and 0.79 + or - 0.3 microg/ml in group 1 and 0.82 + or - 0.4 and 1.55 + or - 1.0 in group 2, respectively.<br />Conclusions: In this sample, the multidrug therapy had no effect on the clinical evolution, incidence of adverse events and plasma thalidomide levels.

Details

Language :
Portuguese
ISSN :
1678-9849
Volume :
43
Issue :
2
Database :
MEDLINE
Journal :
Revista da Sociedade Brasileira de Medicina Tropical
Publication Type :
Academic Journal
Accession number :
20464154
Full Text :
https://doi.org/10.1590/s0037-86822010000200019