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Final report of the amended safety assessment of Quaternium-15 as used in cosmetics.
- Source :
-
International journal of toxicology [Int J Toxicol] 2010 May; Vol. 29 (3 Suppl), pp. 98S-114S. - Publication Year :
- 2010
-
Abstract
- Quaternium-15 is an antimicrobial agent used in cosmetics as a cosmetic preservative and antistatic agent. Little systemic toxicity was reported in most single-dose or repeated-dose animal studies. Quaternium-15 was an oral teratogen, but not a dermal teratogen, in rats at doses that exceeded the expected cumulative exposure from cosmetics. The frequency of sensitization increased in North America but not in Europe, where Quaternium-15 is used less often. In almost all animal and human studies, Quaternium-15 at 0.2% was not a sensitizer. The weight of evidence suggested that a 0.2% concentration is not a sensitizer and that cosmetic products containing Quaternium-15 up to that level are safe.
- Subjects :
- Administration, Cutaneous
Administration, Oral
Allergens classification
Animals
Animals, Laboratory
Anti-Infective Agents administration & dosage
Anti-Infective Agents classification
Consumer Product Safety
Humans
Immunization classification
Methenamine administration & dosage
Methenamine classification
Methenamine toxicity
Preservatives, Pharmaceutical administration & dosage
Rats
Risk Assessment
Skin Tests
Teratogens classification
Toxicity Tests
Allergens toxicity
Anti-Infective Agents toxicity
Methenamine analogs & derivatives
Preservatives, Pharmaceutical toxicity
Teratogens toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1092-874X
- Volume :
- 29
- Issue :
- 3 Suppl
- Database :
- MEDLINE
- Journal :
- International journal of toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 20448270
- Full Text :
- https://doi.org/10.1177/1091581810363915