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First case in Italy of acquired resistance to oseltamivir in an immunocompromised patient with influenza A/H1N1v infection.
- Source :
-
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [J Clin Virol] 2010 Jul; Vol. 48 (3), pp. 220-2. Date of Electronic Publication: 2010 May 05. - Publication Year :
- 2010
-
Abstract
- A pandemic influenza A/H1N1v strain with the neuraminidase H274Y mutation was detected in nasal secretions of a 2-year-old leukemic patient with influenza-like illness after 18 days of treatment with oseltamivir. At baseline, no drug-resistant virus was found, while 4 days after treatment initiation a mixture of wild-type and mutated virus was detected. After treatment interruption, the wild type influenza virus re-emerged and became prevalent in nasal secretions after a few days, suggesting the lower fitness of the mutated virus strain. The patient slowly improved concurrently with a decrease in virus load, which resulted negative 42 days after diagnosis. No other drug-resistant influenza A/H1N1v virus strains have been detected in Italy (up to the end of November 2009) since the first case of the novel A/H1N1v virus was identified in the country (May 2009).<br /> (Copyright (c) 2010 Elsevier B.V. All rights reserved.)
- Subjects :
- Amino Acid Substitution genetics
Bodily Secretions virology
Child, Preschool
Female
Humans
Immunocompromised Host
Influenza A Virus, H1N1 Subtype isolation & purification
Influenza, Human drug therapy
Italy
Molecular Sequence Data
Mutation, Missense
Neuraminidase
Nose virology
Oseltamivir therapeutic use
RNA, Viral genetics
Sequence Analysis, DNA
Treatment Outcome
Viral Load
Viral Proteins
Withholding Treatment
Antiviral Agents pharmacology
Drug Resistance, Viral
Influenza A Virus, H1N1 Subtype drug effects
Influenza, Human virology
Oseltamivir pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-5967
- Volume :
- 48
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
- Publication Type :
- Academic Journal
- Accession number :
- 20447860
- Full Text :
- https://doi.org/10.1016/j.jcv.2010.03.027