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Seropositivity to anti-phenolic glycolipid-I in leprosy cases, contacts and no known contacts of leprosy in an endemic and a non-endemic area in northeast Brazil.
- Source :
-
Transactions of the Royal Society of Tropical Medicine and Hygiene [Trans R Soc Trop Med Hyg] 2010 Jul; Vol. 104 (7), pp. 490-5. Date of Electronic Publication: 2010 May 06. - Publication Year :
- 2010
-
Abstract
- The seroprevalence rates of IgM anti-phenolic glycolipid-I (PGL-I) antibodies in four study groups with differing exposure to Mycobacterium leprae in Ceará, Brazil were investigated between March 2005 and August 2006. The first three groups in a high prevalence area included 144 cases of leprosy, their 380 contacts and 317 participants with no known leprosy contact. The fourth group in a low prevalence area consisted of 87 participants with no known leprosy contact living in an area in which no cases of leprosy had been reported in the previous 6 months. Seropositivity and levels of IgM antibodies to PGL-I were investigated using ELISA. The seropositivity levels of anti-PGL-I among the different clinical forms of leprosy cases were 61% for lepromatous, 25% for tuberculoid and 27% indeterminate. The levels of anti-PGL-I antibodies in the endemic area differentiated leprosy cases from non-cases. However, the seropositivity was similar among contact cases (15.8%) and no known leprosy contact cases from high (15.1%) and low (13.8%) prevalence areas. The seropositivity of both contacts and no known contacts was much higher than previously reported among no known contacts in other endemic areas. The study indicates that anti-PGL-I antibodies are not useful as immunological markers of household leprosy contacts and no known leprosy contacts in endemic areas.<br /> (Copyright 2010 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Antibodies, Bacterial immunology
Biomarkers blood
Brazil epidemiology
Contact Tracing
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunoglobulin M immunology
Leprosy blood
Leprosy epidemiology
Leprosy, Lepromatous blood
Leprosy, Lepromatous epidemiology
Leprosy, Lepromatous immunology
Leprosy, Tuberculoid blood
Leprosy, Tuberculoid epidemiology
Leprosy, Tuberculoid immunology
Male
Middle Aged
Seroepidemiologic Studies
Young Adult
Antibodies, Bacterial blood
Antigens, Bacterial immunology
Glycolipids immunology
Immunoglobulin M blood
Leprosy immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1878-3503
- Volume :
- 104
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Transactions of the Royal Society of Tropical Medicine and Hygiene
- Publication Type :
- Academic Journal
- Accession number :
- 20447668
- Full Text :
- https://doi.org/10.1016/j.trstmh.2010.03.006