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L-histidine decarboxylase and Tourette's syndrome.

Authors :
Ercan-Sencicek AG
Stillman AA
Ghosh AK
Bilguvar K
O'Roak BJ
Mason CE
Abbott T
Gupta A
King RA
Pauls DL
Tischfield JA
Heiman GA
Singer HS
Gilbert DL
Hoekstra PJ
Morgan TM
Loring E
Yasuno K
Fernandez T
Sanders S
Louvi A
Cho JH
Mane S
Colangelo CM
Biederer T
Lifton RP
Gunel M
State MW
Source :
The New England journal of medicine [N Engl J Med] 2010 May 20; Vol. 362 (20), pp. 1901-8. Date of Electronic Publication: 2010 May 05.
Publication Year :
2010

Abstract

Tourette's syndrome is a common developmental neuropsychiatric disorder characterized by chronic motor and vocal tics. Despite a strong genetic contribution, inheritance is complex, and risk alleles have proven difficult to identify. Here, we describe an analysis of linkage in a two-generation pedigree leading to the identification of a rare functional mutation in the HDC gene encoding L-histidine decarboxylase, the rate-limiting enzyme in histamine biosynthesis. Our findings, together with previously published data from model systems, point to a role for histaminergic neurotransmission in the mechanism and modulation of Tourette's syndrome and tics.<br /> (2010 Massachusetts Medical Society)

Details

Language :
English
ISSN :
1533-4406
Volume :
362
Issue :
20
Database :
MEDLINE
Journal :
The New England journal of medicine
Publication Type :
Academic Journal
Accession number :
20445167
Full Text :
https://doi.org/10.1056/NEJMoa0907006