Phosphorylation of additional sites on pyruvate dehydrogenase inhibits its re-activation by pyruvate dehydrogenase phosphate phosphatase.

Authors :: Sugden PH
Hutson NJ
Kerbey AL
Randle PJ
Source :: The Biochemical journal [Biochem J] 1978 Feb 01; Vol. 169 (2), pp. 433-5.
Publication Year :: 1978
Abstract: The phosphorylation of sites additional to an inactivating site inhibits the formation of active pig heart pyruvate dehydrogenase complex from inactive pyruvate dehydrogenase phosphate complex by pig heart pyruvate dehydrogenase phosphate phosphatase.

Subjects :: Animals
Binding Sites
Kinetics
Myocardium enzymology
Phosphates metabolism
Phosphoproteins metabolism
Swine
Phosphoric Monoester Hydrolases metabolism
Pyruvate Dehydrogenase (Lipoamide)-Phosphatase metabolism
Pyruvate Dehydrogenase Complex antagonists & inhibitors

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