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Enhancing chemotherapeutic drug inhibition on tumor growth by ultrasound: an in vivo experiment.
- Source :
-
Journal of drug targeting [J Drug Target] 2011 Feb; Vol. 19 (2), pp. 154-60. Date of Electronic Publication: 2010 Apr 30. - Publication Year :
- 2011
-
Abstract
- An in vivo study on enhancing epirubicin hydrochloride (EPI) inhibition on tumor growth by ultrasound (US) was reported. Five-week-old male nude mice were used and HL-60 cells were s.c. (subcutaneous injection) inoculated in axilla of these mice. Six groups were designed and five consecutive treatments were applied to investigate the inhibition on tumor growth and body weight growth. US applied locally to the tumor resulted in a substantially increased drug uptake in tumor cells. The inhibition on tumor growth depended on the position of drug injection and phospholipid-based microbubble (PMB) application. Tumor growth rate under group 1 (PMB+US) was similar to that of blank control. The order of the inhibition on tumor volume growth was: group 4 (s.c. EPI+PMB+US) > group 5 intraperitoneal (i.p. EPI+PMB+US) > group 2 (i.p. EPI) > group 3 (s.c. EPI+US) > group 1 (PMB+US). Similar conclusion was obtained from experimental measurements of tumor weight change. The order of animal survival status for EPI administration groups was: group 4 > group 5 > group 2 > group 3. Chemotherapeutic drug inhibition on tumor growth could be enhanced by local US combined with PMB, which might provide a potential application for US-mediated chemotherapy.
- Subjects :
- Animals
Antibiotics, Antineoplastic pharmacokinetics
Antibiotics, Antineoplastic pharmacology
Drug Delivery Systems
Drug Screening Assays, Antitumor methods
Epirubicin pharmacokinetics
Epirubicin pharmacology
HL-60 Cells
Humans
Leukemia, Promyelocytic, Acute pathology
Male
Mice
Mice, Inbred BALB C
Mice, Nude
Microbubbles
Phospholipids chemistry
Survival
Antibiotics, Antineoplastic administration & dosage
Epirubicin administration & dosage
Leukemia, Promyelocytic, Acute drug therapy
Ultrasonics methods
Subjects
Details
- Language :
- English
- ISSN :
- 1029-2330
- Volume :
- 19
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of drug targeting
- Publication Type :
- Academic Journal
- Accession number :
- 20429773
- Full Text :
- https://doi.org/10.3109/10611861003801834