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Chronic myelogenous leukemia stem cells: What's new?
- Source :
-
Current hematologic malignancy reports [Curr Hematol Malig Rep] 2009 Apr; Vol. 4 (2), pp. 66-73. - Publication Year :
- 2009
-
Abstract
- Chronic myelogenous leukemia (CML) is a clonal myeloproliferative disorder that arises in the hematopoietic stem cell compartment. CML is one of the best-understood malignancies, as it results from a single genetic mutation, the fusion oncogene BCR-ABL, which has been widely studied. Specific tyrosine kinase inhibitors have been developed to target BCR-ABL in CML, but these agents fail to eliminate the CML stem cell population and thus are unlikely to cure CML. This article reviews recent developments in the biology and treatment of CML, specifically focusing on CML stem cells. Significant progress continues to be made in our understanding of CML stem cell biology, which has wider implications within the cancer stem cell field. We are also beginning to see the identification of novel therapies that specifically target the CML stem cell. These are exciting times in the quest to cure CML.
- Subjects :
- Benzodiazepines administration & dosage
Cell Lineage
Hematopoietic Stem Cells metabolism
Hematopoietic Stem Cells pathology
Humans
Imidazoles administration & dosage
Leukemia, Myelogenous, Chronic, BCR-ABL Positive genetics
Leukemia, Myelogenous, Chronic, BCR-ABL Positive pathology
Models, Biological
Neoplastic Stem Cells metabolism
Neoplastic Stem Cells pathology
Protein Kinase Inhibitors administration & dosage
Treatment Outcome
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Hematopoietic Stem Cells drug effects
Leukemia, Myelogenous, Chronic, BCR-ABL Positive drug therapy
Neoplastic Stem Cells drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1558-822X
- Volume :
- 4
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Current hematologic malignancy reports
- Publication Type :
- Academic Journal
- Accession number :
- 20425417
- Full Text :
- https://doi.org/10.1007/s11899-009-0010-9