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Insecticidal, mutagenic and genotoxic evaluation of annonaceous acetogenins.
- Source :
-
Natural product communications [Nat Prod Commun] 2010 Mar; Vol. 5 (3), pp. 391-4. - Publication Year :
- 2010
-
Abstract
- Annonaceous acetogenins represent a class of bioactive compounds whose primary mode of action is the inhibition of NADH-ubiquinone oxidoreductase (Mitochondrial Complex I). Given the potential pesticidal use of these compounds, we evaluated the effects of seven acetogenins: squamocin (1), molvizarin (2), itrabin (3), almuñequin (4), cherimolin-1 (5), cherimolin-2 (6), and tucumanin (7) isolated from Annona cherimolia Mill. against Ceratitis capitata Wiedemann (Tephritidae). These acetogenins did not display insecticidal action at 250 microg of treatment per g of adult diet. However, the oviposition capacity of C. capitata females was significantly altered by some of the acetogenins at this concentration. The most potent compounds were itrabin, molvizarin and squamocin. Moreover, significant differences were detected in the preference of oviposition sites when itrabin and squamocin were spread on the surface of artificial fruits at doses of 30 microg/cm2. Additionally, we investigated the mutagenic effects displayed by itrabin, as well as the phytotoxic and genotoxic action of squamocin and itrabin. Both compounds displayed slight phytotoxic and genotoxic effects on roots of Allium cepa at 2.5 microg/mL though no mutagenic effects were detected at 0.25, 0.5 and 2.5 microg/mL on Salmonella typhimurium strains TA98 and TA100.
- Subjects :
- Allium drug effects
Allium genetics
Allium growth & development
Animals
Behavior, Animal
Female
Insecticides chemistry
Lactones toxicity
Male
Mutagens chemistry
Oviposition drug effects
Plant Roots drug effects
Plant Roots growth & development
Salmonella typhimurium drug effects
Salmonella typhimurium genetics
Acetogenins chemistry
Acetogenins toxicity
Annonaceae chemistry
Ceratitis capitata physiology
Insecticides toxicity
Mutagens toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1934-578X
- Volume :
- 5
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Natural product communications
- Publication Type :
- Academic Journal
- Accession number :
- 20420314