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Does caffeine impair cerebral oxygenation and blood flow velocity in preterm infants?

Authors :
Tracy MB
Klimek J
Hinder M
Ponnampalam G
Tracy SK
Source :
Acta paediatrica (Oslo, Norway : 1992) [Acta Paediatr] 2010 Sep; Vol. 99 (9), pp. 1319-23.
Publication Year :
2010

Abstract

Aim: The aim of the study is to assess the effects of an intravenous 10 mg/kg loading dose of caffeine base in cerebral oxygenation, cerebral Doppler blood flow velocity and cardiac output in preterm infants.<br />Methods: Preterm neonates <34 weeks gestation were investigated at 1 and 4 h following the loading dose of caffeine using Doppler cerebral sonography, cardiac echocardiography and cerebral spatially resolved near-infrared spectroscopy.<br />Results: Forty infants were studied with a mean gestational age (mean ± standard deviation) of 27.7 (±2.5) weeks, birth weight of 1155 (±431) g and a postnatal age of 2.8 (±2.2) days. Mean Anterior Cerebral Artery peak and time average mean blood flow velocity fell significantly by 14% and 17.7%, respectively at 1 h post-caffeine loading dose, which recovered partially by 4 h. Cerebral Tissue Oxygenation Index fell from pre-dose levels by 9.5% at 1 h with partial recovery to 4.9% reduced at 4 h post-dose. There were no significant changes in left or right ventricular output, transcutaneous oxygen saturation, transcutaneous PCO(2) or total vascular resistance.<br />Conclusions: A loading dose of 10 mg/kg caffeine base resulted in significant reduction at 1 h post-dose in cerebral oxygenation and cerebral blood flow velocity with partial recovery at 4 h.<br /> (© 2010 The Author(s)/Journal Compilation © 2010 Foundation Acta Paediatrica.)

Details

Language :
English
ISSN :
1651-2227
Volume :
99
Issue :
9
Database :
MEDLINE
Journal :
Acta paediatrica (Oslo, Norway : 1992)
Publication Type :
Academic Journal
Accession number :
20412101
Full Text :
https://doi.org/10.1111/j.1651-2227.2010.01828.x