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[Effects of statin use on intracranial hemorrhage and clinical outcome after intravenous rt-PA for acute ischemic stroke: SAMURAI rt-PA registry].
- Source :
-
Rinsho shinkeigaku = Clinical neurology [Rinsho Shinkeigaku] 2010 Apr; Vol. 50 (4), pp. 225-31. - Publication Year :
- 2010
-
Abstract
- Purpose: We evaluated whether pre- and post-stroke statin use was associated with intracranial hemorrhage (ICH) and clinical outcome at 3 months after intravenous recombinant tissue plasminogen activator (IV rt-PA) for acute ischemic stroke.<br />Methods: This study enrolled 600 consecutive patients (72 +/- 12 years, woman 37.2%) who received IV rt-PA at ten stroke centers that participated in the SAMURAI rt-PA Registry from October 2005 to July 2008.<br />Results: Statins were used prior to stroke in 112% and within 72 h after IV rt-PA in 10.0% of patients. One hundred nineteen patients (19.8%) developed ICH. Pre-stroke statin use was not an independent factor associated with ICH (OR 1.46; 95% CI 0.76-2.81, p = 0.225). Of 535 patients with a premorbid mRS < or = 1, 199 (37.2%) had a favorable clinical outcome at 3 months (mRS < or = 1). Pre-stroke statin use (OR 1.05; 95% CI 0.55-2.01, p = 0.879), as well as post-stroke statin use (OR 1.31; 95% CI 0.66-2.59, p = 0.440), was not an independent predictor of outcome.<br />Conclusions: In patients who received IV rt-PA for acute ischemic stroke, statin use did not increase ICH after thrombolysis, nor was it associated with clinical outcome.
- Subjects :
- Acute-Phase Reaction
Aged
Female
Humans
Infusions, Intravenous
Male
Middle Aged
Streptonigrin
Treatment Outcome
Fibrinolytic Agents administration & dosage
Hydroxymethylglutaryl-CoA Reductase Inhibitors administration & dosage
Stroke drug therapy
Tissue Plasminogen Activator administration & dosage
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0009-918X
- Volume :
- 50
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Rinsho shinkeigaku = Clinical neurology
- Publication Type :
- Academic Journal
- Accession number :
- 20411804
- Full Text :
- https://doi.org/10.5692/clinicalneurol.50.225