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Default-mode network dysfunction and cognitive impairment in progressive MS.
- Source :
-
Neurology [Neurology] 2010 Apr 20; Vol. 74 (16), pp. 1252-9. - Publication Year :
- 2010
-
Abstract
- Objective: This study explores default-mode network (DMN) abnormalities in patients with secondary progressive (SP) and primary progressive (PP) multiple sclerosis (MS) and whether such abnormalities correlate with cognitive impairment and damage to selected white matter (WM) fiber bundles, quantified using diffusion tensor (DT) MRI tractography.<br />Methods: Resting state (RS) functional MRI and DT MRI data were acquired from 33 patients with SPMS, 24 patients with PPMS, and 24 controls. Independent component analysis (ICA) was used to identify the DMN. SPM5 was used to assess within- and between-group activations.<br />Results: Between-group differences in DMN activity were found in the left medial prefrontal cortex (mPFC), left precentral gyrus (PcG), and anterior cingulate cortex (ACC). Compared to controls, patients with SPMS had reduced activity in the mPFC (p = 0.01) and PcG (p = 0.02), while patients with PPMS had reduced activity in the PcG (p = 0.008) and the ACC (p = 0.002). Compared to patients with PPMS, patients with SPMS had increased ACC activity (p = 0.04). Reduction of RS activity in the ACC was more pronounced in cognitively impaired vs cognitively preserved patients with MS (p = 0.02). In patients with MS, DMN abnormalities correlated with the PASAT and word list test scores (r values ranging from 0.35 to 0.45) and DT MRI changes in the corpus callosum and the cingulum (r values ranging from 0.82 to 0.87).<br />Conclusion: These results suggest that a dysfunction of the anterior components of the default-mode network may be among the factors responsible for the accumulation of cognitive deficits in patients with progressive multiple sclerosis.
- Subjects :
- Adult
Aged
Brain pathology
Brain Mapping
Cognition Disorders etiology
Cognition Disorders pathology
Diffusion Tensor Imaging
Disability Evaluation
Disease Progression
Female
Functional Laterality physiology
Gyrus Cinguli pathology
Gyrus Cinguli physiopathology
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Motor Cortex pathology
Motor Cortex physiopathology
Multiple Sclerosis, Chronic Progressive pathology
Multiple Sclerosis, Chronic Progressive psychology
Nerve Fibers, Myelinated pathology
Nerve Net pathology
Neuropsychological Tests
Predictive Value of Tests
Prefrontal Cortex pathology
Prefrontal Cortex physiopathology
Prognosis
Sensitivity and Specificity
Young Adult
Brain physiopathology
Cognition Disorders physiopathology
Multiple Sclerosis, Chronic Progressive physiopathology
Nerve Net physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1526-632X
- Volume :
- 74
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 20404306
- Full Text :
- https://doi.org/10.1212/WNL.0b013e3181d9ed91