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Diterpenoids from the feces of Trogopterus xanthipes.
- Source :
-
Journal of natural products [J Nat Prod] 2010 May 28; Vol. 73 (5), pp. 865-9. - Publication Year :
- 2010
-
Abstract
- Three new isopimarane diterpenoids, trogopteroids A-C (1-3), four new aromatic diterpenoids, trogopteroids D-G (4-7), and 12 known diterpenoids were isolated from the feces of Trogopterus xanthipes. Their structures were identified using spectroscopic methods. The relative configuration of 1 was confirmed by quantum calculations. Compound 1 represents the first example of a norisopimarane diterpenoid with an 8alpha,15alpha-olide ring. With the exception of compound 14, all diterpenoids were evaluated for cytotoxicity against seven human tumor cell lines.
- Subjects :
- Animals
Antineoplastic Agents, Phytogenic chemistry
Antineoplastic Agents, Phytogenic pharmacology
China
Diterpenes chemistry
Diterpenes pharmacology
Drug Screening Assays, Antitumor
Humans
Inhibitory Concentration 50
Antineoplastic Agents, Phytogenic isolation & purification
Diterpenes isolation & purification
Feces chemistry
Sciuridae metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1520-6025
- Volume :
- 73
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 20402524
- Full Text :
- https://doi.org/10.1021/np900814s