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Treatment with topical tacrolimus favors chronic actinic dermatitis: a clinical and immunopathological study.
- Source :
-
The Journal of dermatological treatment [J Dermatolog Treat] 2010 May; Vol. 21 (3), pp. 171-7. - Publication Year :
- 2010
-
Abstract
- Background: Previous studies have demonstrated the efficacy and safety of tacrolimus ointment in the treatment of atopic dermatitis (AD); however, few have investigated the effect of tacrolimus on chronic actinic dermatitis (CAD).<br />Objectives: To investigate the efficacy and safety of tacrolimus ointment on CAD and its mechanism of treatment.<br />Methods: Forty adult patients with CAD were treated with 0.1% tacrolimus ointment. Skin biopsies were performed on 15 patients before and after treatment. The specimens were subjected to immunohistochemical staining with a panel of monoclonal antibodies to CD1a, CD11b, and CC chemokine receptor 7.<br />Results: Among all the 40 patients, two (5%) were clinically cured and 23 (57.5%) achieved excellent results, making a total effective rate of 62.5%; 14 (35%) were improved; and one (2.5%) case was withdrawn due to intolerable itching at the locally applied areas. CD1a, CD11b and CCR7 expression were all significantly down-regulated after topical treatment with tacrolimus.<br />Conclusions: Treatment with topical tacrolimus is effective and safe for chronic actinic dermatitis, probably due to suppression of the function of Langerhans' cells and inflammatory dendritic epidermal cells and their relevant cytokines.
- Subjects :
- Administration, Topical
Adult
Antibodies, Monoclonal analysis
Antibodies, Monoclonal immunology
Biopsy, Needle
Cohort Studies
Female
Follow-Up Studies
Humans
Immunohistochemistry
Male
Middle Aged
Ointments therapeutic use
Photosensitivity Disorders immunology
Receptors, Chemokine
Risk Assessment
Skin Absorption drug effects
Treatment Outcome
Immunosuppressive Agents therapeutic use
Photosensitivity Disorders drug therapy
Photosensitivity Disorders pathology
Tacrolimus therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1471-1753
- Volume :
- 21
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of dermatological treatment
- Publication Type :
- Academic Journal
- Accession number :
- 20394493
- Full Text :
- https://doi.org/10.3109/09546630903575547