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Apoptosis: conserved roles for integrins in clearance.

Authors :
D'mello V
Birge RB
Source :
Current biology : CB [Curr Biol] 2010 Apr 13; Vol. 20 (7), pp. R324-7.
Publication Year :
2010

Abstract

A recent study shows that one of the two known Caenorhabditis elegans homologs of the mammalian integrin alpha subunit plays an essential role in the clearance of apoptotic cells - efferocytosis - during nematode development. These new findings reveal that integrins have evolutionarily conserved functions in efferocytosis in metazoans.

Subjects

Subjects :
Animals
Apoptosis genetics
Caenorhabditis elegans cytology
Caenorhabditis elegans genetics
Caenorhabditis elegans physiology
Caenorhabditis elegans Proteins genetics
Caenorhabditis elegans Proteins physiology
Humans
Integrin alpha Chains genetics
Integrin alpha Chains physiology
Integrins genetics
Models, Biological
Phagocytosis physiology
Signal Transduction
Apoptosis physiology
Integrins physiology

Details

Language :
English
ISSN :
1879-0445
Volume :
20
Issue :
7
Database :
MEDLINE
Journal :
Current biology : CB
Publication Type :
Academic Journal
Accession number :
20392425
Full Text :
https://doi.org/10.1016/j.cub.2010.02.043
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