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Central precocious puberty due to hypothalamic hamartomas correlates with anatomic features but not with expression of GnRH, TGFalpha, or KISS1.
- Source :
-
Hormone research in paediatrics [Horm Res Paediatr] 2010; Vol. 73 (5), pp. 312-9. Date of Electronic Publication: 2010 Apr 14. - Publication Year :
- 2010
-
Abstract
- Background/aims: Hypothalamic hamartomas are the most common identifiable cause of central precocious puberty (CPP). Hamartoma characteristics proposed to be associated with CPP include specific anatomic features and expression of molecules such as gonadotropin-releasing hormone (GnRH), transforming growth factor alpha (TGFalpha), and GRM1A, which encodes the type 1 metabotropic glutamate receptor alpha isoform. We sought to determine whether hamartomas that cause CPP could be distinguished by anatomic features, expression of these molecules, or expression of KISS1, whose products signal through the receptor GPR54 to stimulate GnRH release.<br />Methods: Clinical records and radiologic images were reviewed for 18 patients who underwent hamartoma resection for intractable seizures; 7 had precocious puberty. Resected tissue was examined for expression of GnRH, GnRH receptor (GnRHR), TGFalpha, KISS1, GPR54, and GRM1A.<br />Results: Hypothalamic hamartomas associated with CPP were more likely to contact the infundibulum or tuber cinereum and were larger than hamartomas not associated with CPP. GnRH, TGFalpha, and GnRHR were expressed by all hamartomas studied. Expression of KISS1, GPR54, and GRM1A did not differ significantly between hamartomas associated and not associated with CPP.<br />Conclusion: Anatomic features rather than expression patterns of candidate molecules distinguish hypothalamic hamartomas that are associated with CPP from those that are not.<br /> (Copyright 2010 S. Karger AG, Basel.)
- Subjects :
- Adolescent
Child
Child, Preschool
Female
Gene Expression
Hamartoma diagnostic imaging
Hamartoma metabolism
Hamartoma pathology
Hamartoma surgery
Humans
Hypothalamic Diseases diagnostic imaging
Hypothalamic Diseases pathology
Infant
Kisspeptins
Male
Puberty, Precocious pathology
Radiography
Receptors, LHRH biosynthesis
Seizures etiology
Seizures surgery
Gonadotropin-Releasing Hormone biosynthesis
Hamartoma complications
Hypothalamic Diseases complications
Puberty, Precocious etiology
Transforming Growth Factor alpha biosynthesis
Tumor Suppressor Proteins biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1663-2826
- Volume :
- 73
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Hormone research in paediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 20389100
- Full Text :
- https://doi.org/10.1159/000308162