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Contrast-enhanced ultrasound for imaging vasa vasorum: comparison with histopathology in a swine model of atherosclerosis.
- Source :
-
European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology [Eur J Echocardiogr] 2010 Sep; Vol. 11 (8), pp. 659-64. Date of Electronic Publication: 2010 Apr 12. - Publication Year :
- 2010
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Abstract
- Aim: To evaluate the agreement between contrast-enhanced ultrasound imaging and histopathology in an animal model of atherosclerosis.<br />Methods and Results: Atherosclerosis was studied in both femoral arteries of four Rapacz familial hypercholesterolaemia (RFH) swine. Contrast-enhanced ultrasound imaging of the eight femoral arteries was performed at baseline and at 5, 12, 26, and 43 weeks follow-up after percutaneous transluminal stimulation of atherosclerosis to assess the progression of intima-media thickness (IMT) and the density and extent of the vasa vasorum network. Contrast-enhanced ultrasound imaging allowed an early detection of atherosclerosis and showed a significant gradual progression of atherosclerosis over time. IMT increased from 0.22 +/- 0.05 mm at baseline to 0.45 +/- 0.06 mm (P < 0.001) at follow-up. The density of the vasa vasorum network increased during follow-up and was significantly higher in advanced than in early atherosclerosis. The findings with contrast-enhanced ultrasound were confirmed by histopathological specimens of the arterial wall.<br />Conclusion: Contrast-enhanced ultrasound is effective for in vivo detection of vasa vasorum in atherosclerotic plaques in the RFH swine model. After stimulation of atherosclerosis, contrast-enhanced ultrasound demonstrated a significantly increased IMT and significantly increased density of the vasa vasorum network in the developing atherosclerotic plaque, which was validated by histology.
- Subjects :
- Animals
Arteriosclerosis pathology
Disease Models, Animal
Disease Progression
Hyperlipoproteinemia Type II pathology
Radionuclide Imaging
Swine
Time Factors
Tunica Intima pathology
Tunica Media pathology
Ultrasonography
Vasa Vasorum pathology
Arteriosclerosis diagnostic imaging
Contrast Media
Hyperlipoproteinemia Type II diagnostic imaging
Tunica Intima diagnostic imaging
Tunica Media diagnostic imaging
Vasa Vasorum diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1532-2114
- Volume :
- 11
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 20385655
- Full Text :
- https://doi.org/10.1093/ejechocard/jeq048