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Identification of benzimidazole-based inhibitors of the mitogen activated kinase-5 signaling pathway.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 May 01; Vol. 20 (9), pp. 2892-6. Date of Electronic Publication: 2010 Mar 10. - Publication Year :
- 2010
-
Abstract
- The MEK-signaling pathways are complex but critical signaling cascades that correlate an extracellular signaling event with internal cell processes. To date at least seven MEK isozymes have been identified. MEK5, in particular, is upregulated in multiple forms of tumors. Analysis of the EGF-induced MEK5 signaling cascade in cultured HEK cells has identified compounds that can inhibit MEK5 phosphorylation of ERK5; observed biological activity is dependent on chemical variation.<br /> (2010 Elsevier Ltd. All rights reserved.)
- Subjects :
- Benzimidazoles chemical synthesis
Benzimidazoles pharmacology
Cell Line
Epidermal Growth Factor pharmacology
Humans
MAP Kinase Kinase 5 metabolism
Mitogen-Activated Protein Kinase 7 metabolism
Phosphorylation
Protein Kinase Inhibitors chemical synthesis
Protein Kinase Inhibitors pharmacology
Benzimidazoles chemistry
MAP Kinase Kinase 5 antagonists & inhibitors
Protein Kinase Inhibitors chemistry
Signal Transduction drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 20
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 20382528
- Full Text :
- https://doi.org/10.1016/j.bmcl.2010.03.033