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Effects of topical application of alpha-D-glucosylglycerol on dermal levels of insulin-like growth factor-i in mice and on facial skin elasticity in humans.
- Source :
-
Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2010; Vol. 74 (4), pp. 759-65. Date of Electronic Publication: 2010 Apr 07. - Publication Year :
- 2010
-
Abstract
- Sensory neurons release calcitonin-gene related peptide (CGRP) on stimulation. We have reported that topical application of capsaicin increases facial skin elasticity by increasing the production of dermal insulin-like growth factor-I (IGF-I) through stimulation of sensory neurons in mice and humans. In this study, we examined whether topical application of alpha-D-glucosylglycerol (GG), a compound found in Japanese traditional brewed foods such as sake (Japanese rice wine), increases the dermal production of IGF-I in mice and increases the facial skin elasticity in females. GG increased CGRP release and cAMP levels in dorsal root ganglion (DRG) neurons isolated from wild-type mice. Pretreatment with capsazepine, an inhibitor of vanilloid receptor-1 activation, and with KT5720, an inhibitor of protein kinase A, reversed GG-induced increases in CGRP release from DRG neurons. Topical application of GG increased dermal levels of IGF-I, IGF-I mRNA, and collagen in wild-type mice, but not in CGRP-knockout mice. Topical application of GG increased cheek-skin elasticity in 13 female volunteers. These observations strongly suggest that GG increases the production of IGF-I in the skin through sensory neuron stimulation, thereby increasing skin elasticity.
- Subjects :
- Administration, Topical
Animals
Capsaicin analogs & derivatives
Capsaicin metabolism
Capsaicin pharmacology
Carbazoles
Dermis metabolism
Elasticity drug effects
Face
Female
Ganglia, Spinal drug effects
Ganglia, Spinal metabolism
Genes drug effects
Glucosides
Humans
Insulin-Like Growth Factor I genetics
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Neurons, Afferent drug effects
Neurons, Afferent metabolism
Pyrroles
RNA, Messenger genetics
RNA, Messenger metabolism
Sensory Receptor Cells drug effects
Sensory Receptor Cells metabolism
Skin metabolism
TRPV Cation Channels
Insulin-Like Growth Factor I biosynthesis
Insulin-Like Growth Factor I metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1347-6947
- Volume :
- 74
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Bioscience, biotechnology, and biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 20378988
- Full Text :
- https://doi.org/10.1271/bbb.90797