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Association between lipodystrophy and leptin in human immunodeficiency virus-1-infected children receiving lopinavir/ritonavir-based therapy.
- Source :
-
The Pediatric infectious disease journal [Pediatr Infect Dis J] 2010 Aug; Vol. 29 (8), pp. 774-7. - Publication Year :
- 2010
-
Abstract
- Highly active antiretroviral therapy might lead to the development of dyslipidemia and lipodystrophy (LD) syndrome. We carried out a multicenter prospective study of 22 human immunodeficiency virus (HIV)-1-infected children treated during 48 months with lopinavir/ritonavir-based highly active antiretroviral therapy to evaluate the trend of serum lipids and adipokines. Increase in plasma leptin levels and leptin/adiponectin ratio was associated with LD. These adipokines may be surrogate markers of LD.
- Subjects :
- Adolescent
Anti-HIV Agents therapeutic use
Antiretroviral Therapy, Highly Active methods
Biomarkers
Child
Child, Preschool
HIV-1
Humans
Infant
Lopinavir
Prospective Studies
Pyrimidinones therapeutic use
Ritonavir therapeutic use
Anti-HIV Agents adverse effects
HIV Infections complications
HIV Infections drug therapy
HIV-Associated Lipodystrophy Syndrome chemically induced
Leptin blood
Pyrimidinones adverse effects
Ritonavir adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1532-0987
- Volume :
- 29
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- The Pediatric infectious disease journal
- Publication Type :
- Academic Journal
- Accession number :
- 20375850
- Full Text :
- https://doi.org/10.1097/INF.0b013e3181db741b