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Quantification of taurodontism: interests in the early diagnosis of hypohidrotic ectodermal dysplasia.
- Source :
-
Oral diseases [Oral Dis] 2010 Apr; Vol. 16 (3), pp. 292-8. - Publication Year :
- 2010
-
Abstract
- Objective: The aim of this study was to provide a quantification of taurodontism in Hypohidrotic Ectodermal Dysplasia (HED) and to report its occurrence in a cohort of HED patients to assess phenotypic-genotypic correlations.<br />Patients and Methods: Of 68 HED patients retrospectively reviewed, 16 patients aged 7-51 years were selected and compared with a control sample (n = 351). The pulp surface index of the first lower permanent molar was calculated from the panoramic radiograph of each individual, and statistical comparisons between the HED patients and the control sample were performed.<br />Results: Whatever the genetic disorder, 81.25% of the HED patients exhibited a relative enlargement (>or=1 s.d.) of the pulp. Major deviations (>5 s.d.) were respectively related to men affected by large deletion of the EDA gene or missense mutation. The autosomal recessive form was linked to a relative moderate pulp enlargement (3.44 s.d.). In NEMO forms, the increase of pulp size in men appeared to be less marked than in EDA mutations.<br />Conclusion: This study provides for the first time an objective assessment of pulp enlargement in HED patients, and the various degrees of taurodontism depicted could be interesting dental phenotypic markers of HED forms.
- Subjects :
- Adolescent
Adult
Case-Control Studies
Child
Child, Preschool
DNA Mutational Analysis
Dental Pulp Cavity diagnostic imaging
Ectodermal Dysplasia 1, Anhidrotic complications
Ectodermal Dysplasia 1, Anhidrotic genetics
Ectodermal Dysplasia 3, Anhidrotic complications
Ectodermal Dysplasia 3, Anhidrotic genetics
Ectodermal Dysplasia, Hypohidrotic, Autosomal Recessive complications
Ectodermal Dysplasia, Hypohidrotic, Autosomal Recessive genetics
Ectodysplasins genetics
Female
Humans
I-kappa B Kinase genetics
Male
Middle Aged
Molar abnormalities
Molar diagnostic imaging
Mutation, Missense
Radiography
Retrospective Studies
Sequence Deletion
Tooth Abnormalities etiology
Young Adult
Dental Pulp Cavity abnormalities
Ectodermal Dysplasia 1, Anhidrotic diagnosis
Ectodermal Dysplasia 3, Anhidrotic diagnosis
Ectodermal Dysplasia, Hypohidrotic, Autosomal Recessive diagnosis
Tooth Abnormalities genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1601-0825
- Volume :
- 16
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Oral diseases
- Publication Type :
- Academic Journal
- Accession number :
- 20374512
- Full Text :
- https://doi.org/10.1111/j.1601-0825.2009.01641.x