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EGFL7: a new player in homeostasis of the nervous system.
- Source :
-
Cell cycle (Georgetown, Tex.) [Cell Cycle] 2010 Apr 01; Vol. 9 (7), pp. 1263-9. - Publication Year :
- 2010
-
Abstract
- EGFL7 drives the formation of neurons from neural stem cells. In the embryonic and adult brain this process is essential for neurogenesis and homeostasis of the nervous system. The function of adult neurogenesis is not fully understood but maybe it supports life-long learning and brain repair after injuries such as stroke. The transition of neural stem cells into mature neurons is tightly regulated. One of the essential signaling pathways governing this process is the Notch pathway, which controls metazoan development. In a recent publication, we identified a novel non-canonical Notch ligand, EGFL7, and described its impact on neural stem cells. We explored the molecular mechanisms, which this molecule affects to regulate the self-renewal capacity of neural stem cells and to promote their differentiation into neurons. In this review, we discuss the implications of our findings for adult neurogenesis and illustrate the potential of EGFL7 to serve as an agent to increase neurogenesis and the self-renewal potential of the brain
- Subjects :
- Animals
Calcium-Binding Proteins
Cell Differentiation genetics
Cell Differentiation physiology
EGF Family of Proteins
Endothelial Growth Factors genetics
Humans
Mice
Nervous System metabolism
Neural Stem Cells cytology
Neurogenesis genetics
Neurogenesis physiology
Proteins genetics
Proteins metabolism
Receptors, Notch genetics
Receptors, Notch metabolism
Signal Transduction genetics
Signal Transduction physiology
Endothelial Growth Factors metabolism
Neural Stem Cells metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1551-4005
- Volume :
- 9
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Cell cycle (Georgetown, Tex.)
- Publication Type :
- Academic Journal
- Accession number :
- 20372059
- Full Text :
- https://doi.org/10.4161/cc.9.7.11091