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Antibiotic treatment of exacerbations of COPD in general practice: long-term impact on health-related quality of life.
- Source :
-
International journal of chronic obstructive pulmonary disease [Int J Chron Obstruct Pulmon Dis] 2010 Feb 18; Vol. 5, pp. 11-9. Date of Electronic Publication: 2010 Feb 18. - Publication Year :
- 2010
-
Abstract
- Objective: To investigate the impact of exacerbations in health-related quality of life (HRQL) of patients with COPD and to compare the effect of treatment of COPD exacerbations with moxifloxacin (400 mg/day for 5 days) and amoxicillin/clavulanate (500/125 mg 3 times a day for 10 days) on HRQL.<br />Methods: 229 outpatients with stable COPD (mean age 68.2 years; mean FEV(1) % predicted 49.3%) participated in a prospective, observational study of 2 years' duration. The St George's Respiratory Questionnaire (SGRQ) was completed at baseline and every 6 months thereafter.<br />Results: COPD exacerbations (mean 2.7 episodes/patient) occurred in 136 patients (124 patients received the study medications [amoxicillin/clavulanate 54, moxifloxacin 70]). Differences between baseline and the final visit were higher for moxifloxacin compared with amoxicillin/clavulanate for total SGRQ score (-2.60 [13.1] vs 4.21 [16.2], P = 0.05) and "Symptoms" subscale (-5.64 [16.7] vs 8.27 [21], P = 0.02). The same findings were observed in patients with two or more exacerbations.<br />Conclusions: In COPD outpatients, treatment of exacerbations with moxifloxacin had a more favorable long-term effect on quality of life than amoxicillin/clavulanate.
- Subjects :
- Aged
Cohort Studies
Female
Humans
Male
Middle Aged
Observation
Practice Patterns, Physicians'
Prospective Studies
Pulmonary Disease, Chronic Obstructive physiopathology
Spain
Anti-Bacterial Agents therapeutic use
Family Practice
Health Status
Pulmonary Disease, Chronic Obstructive drug therapy
Quality of Life
Subjects
Details
- Language :
- English
- ISSN :
- 1178-2005
- Volume :
- 5
- Database :
- MEDLINE
- Journal :
- International journal of chronic obstructive pulmonary disease
- Publication Type :
- Academic Journal
- Accession number :
- 20368907
- Full Text :
- https://doi.org/10.2147/copd.s8732