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First case of multidrug-resistant tuberculosis caused by a rare "Beijing-like" genotype of Mycobacterium tuberculosis in Bogotá, Colombia.
- Source :
-
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2010 Jul; Vol. 10 (5), pp. 678-81. Date of Electronic Publication: 2010 Mar 31. - Publication Year :
- 2010
-
Abstract
- This report describes a first case due to a genetically distinct and relatively rare "Beijing-like" strain of Mycobacterium tuberculosis isolated from a 15 years old female patient who died shortly after the initiation of antituberculous therapy with second-line drugs. Positive cultures obtained from lung, kidney and adrenal glands upon autopsy were identified as Mycobacterium tuberculosis complex characterized by an identical 15-banded IS6110-RFLP pattern, and were found to be resistant to all the 4 first-line antituberculous drugs tested (rifampin, isoniazid, ethambutol and streptomycin). Spoligotyping followed by comparison with the SITVIT2 database revealed that the isolate belonged to a rare pattern identified as Spoligotype International Type SIT190, which represents only 1.7% of all the Beijing strains worldwide. We present data on its worldwide distribution and present an evolutionary scenario based on available MIRU typing data.<br /> (Copyright 2010 Elsevier B.V. All rights reserved.)
- Subjects :
- Adolescent
Antitubercular Agents therapeutic use
Bacterial Typing Techniques
Colombia
Female
Humans
Mycobacterium tuberculosis isolation & purification
Tuberculosis, Multidrug-Resistant drug therapy
Mycobacterium tuberculosis genetics
Mycobacterium tuberculosis pathogenicity
Tuberculosis, Multidrug-Resistant microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1567-7257
- Volume :
- 10
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 20362076
- Full Text :
- https://doi.org/10.1016/j.meegid.2010.03.010