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Cadmium stress: an oxidative challenge.
- Source :
-
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine [Biometals] 2010 Oct; Vol. 23 (5), pp. 927-40. Date of Electronic Publication: 2010 Apr 02. - Publication Year :
- 2010
-
Abstract
- At the cellular level, cadmium (Cd) induces both damaging and repair processes in which the cellular redox status plays a crucial role. Being not redox-active, Cd is unable to generate reactive oxygen species (ROS) directly, but Cd-induced oxidative stress is a common phenomenon observed in multiple studies. The current review gives an overview on Cd-induced ROS production and anti-oxidative defense in organisms under different Cd regimes. Moreover, the Cd-induced oxidative challenge is discussed with a focus on damage and signaling as downstream responses. Gathering these data, it was clear that oxidative stress related responses are affected during Cd stress, but the apparent discrepancies observed in between the different studies points towards the necessity to increase our knowledge on the spatial and temporal ROS signature under Cd stress. This information is essential in order to reveal the exact role of Cd-induced oxidative stress in the modulation of downstream responses under a diverse array of conditions.
- Subjects :
- Animals
Antioxidants metabolism
Catalase metabolism
Environmental Pollutants toxicity
Enzyme Induction drug effects
Glutathione metabolism
Glutathione Peroxidase metabolism
Humans
Metallothionein metabolism
Mitochondria drug effects
Mitochondria metabolism
Models, Biological
NADPH Oxidases biosynthesis
Oxidation-Reduction
Reactive Oxygen Species metabolism
Sulfhydryl Compounds metabolism
Superoxide Dismutase metabolism
Cadmium toxicity
Oxidative Stress drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1572-8773
- Volume :
- 23
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 20361350
- Full Text :
- https://doi.org/10.1007/s10534-010-9329-x