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[The study of relationship between platelet function and thrombus in patients with essential thrombocythaemia].
- Source :
-
Zhonghua yi xue za zhi [Zhonghua Yi Xue Za Zhi] 2010 Jan 26; Vol. 90 (4), pp. 253-5. - Publication Year :
- 2010
-
Abstract
- Objective: To observe the influence of the plasma thromboxane B2 (TXB2), 6-keto-PGF1alpha, CD62P and PAC-1 and Thrombus in patients with primary thrombocytosis (ET). To observe the effect of sodium ozagrel to prevent and treat thrombosis in patients with ET.<br />Methods: The subjects including 48 patients with ET. All patients were measured the plasma TXB2, 6-keto-PGF1alpha, CD62P and PAC-1 before and after treatment with or without sodium ozagrel.<br />Results: The plasma levels of CD62P, PAC-1, TXB2, 6-keto-PGF1alpha and TXA2/PGI2 in the patients with ET were significantly higher than the normal people (P < 0.01). The levels of CD62P, PAC-1, TXB2, TXB2/6-keto-PGF1alpha in patients with treatment of sodium ozagrel were higher than patients without treatment of sodium ozagrel (P < 0.01). The plasma levels of CD62P, PAC-1 and TXA2/PGI2 in patients with treatment of sodium ozagrel and that in normal people had no significant distinction (P < 0.01). All the index of conventional therapy group were higher than normal people (P < 0.01) but had no significant distinction with the patients before conventional treating. The incidence of thrombus in patients treated with sodium ozagrel was lower than patients treated without sodium ozagrel (P < 0.05).<br />Conclusion: With the treatment of sodium ozagrel in patients with ET, the CD62P, PAC-1, TXB2 and TXA2/PGI2 of plasma could be decreased. And the incidence of thrombus was decreased.
- Subjects :
- 6-Ketoprostaglandin F1 alpha blood
Adult
Female
Humans
Male
Middle Aged
P-Selectin blood
Receptors, Fibrinogen immunology
Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I blood
Thrombosis drug therapy
Thromboxane A2 blood
Thromboxane B2 blood
Antibodies, Monoclonal blood
Blood Platelets physiology
Methacrylates therapeutic use
Thrombocythemia, Essential physiopathology
Thrombosis prevention & control
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0376-2491
- Volume :
- 90
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Zhonghua yi xue za zhi
- Publication Type :
- Academic Journal
- Accession number :
- 20356540