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Tropomyosin or not tropomyosin, what is the relevant allergen in house dust mite and snail cross allergies?
Tropomyosin or not tropomyosin, what is the relevant allergen in house dust mite and snail cross allergies?
- Source :
-
European annals of allergy and clinical immunology [Eur Ann Allergy Clin Immunol] 2010 Feb; Vol. 42 (1), pp. 3-10. - Publication Year :
- 2010
-
Abstract
- Since tropomyosin is cross reactive in many arthropods, it was assumed that this highly conserved protein could be responsible for cross reactions in house dust mite (HDM) allergic patients who experienced adverse reactions after crustacean and mollusc ingestion. Here we report two clinical cases where the role of tropomyosin is a matter of debate. In the first case, the clinical history, as well as the results of in vivo and in vitro investigations, are in favour of a shrimp allergy without any snail allergy in a patient sensitized to HDM. In the second, the clinical history and the cutaneous tests are in favour of an allergy to snails without any allergy to shrimps in a patient suffering from HDM allergies. The clinical presentation is different in shrimp and snail allergies. In shrimp allergy, symptoms are mainly urticaria or angio-oedema. In snail allergies, adverse reactions are especially severe asthma. Shrimp tropomyosin is a dominant allergen in crustaceans whereas has a much less prominent role in HDM sensitization. Cross reactivities between HDM and snails have been confirmed by inhibition experiments. However, tropomyosin appears to be a minor allergen or even is not involved in snail allergy. It is necessary to clarify the allergens shared between HDMI and snails. The effects of HDM immunotherapy in snail allergy are questioned. Knowledge of taxonomy can contribute to more precise evaluation of cross reactivities between crustaceans and molluscs.
- Subjects :
- Adult
Allergens adverse effects
Angioedema
Animals
Asthma complications
Asthma diagnosis
Asthma physiopathology
Classification
Female
Food Hypersensitivity complications
Food Hypersensitivity immunology
Food Hypersensitivity physiopathology
Humans
Hypersensitivity complications
Hypersensitivity diagnosis
Hypersensitivity physiopathology
Middle Aged
Penaeidae immunology
Pyroglyphidae immunology
Shellfish adverse effects
Skin Tests
Snails immunology
Urticaria
Allergens immunology
Asthma immunology
Cross Reactions immunology
Hypersensitivity immunology
Tropomyosin immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1764-1489
- Volume :
- 42
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- European annals of allergy and clinical immunology
- Publication Type :
- Academic Journal
- Accession number :
- 20355359