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Radiation-induced cerebellar high-grade glioma accompanied by meningioma and cavernoma 29 years after the treatment of medulloblastoma: a case report.
- Source :
-
Journal of neuro-oncology [J Neurooncol] 2010 Nov; Vol. 100 (2), pp. 299-303. Date of Electronic Publication: 2010 Mar 31. - Publication Year :
- 2010
-
Abstract
- Here, we report the case of a patient with cerebellar high-grade glioma that developed after the patient underwent treatment for medulloblastoma. A 34-year-old man visited our hospital with complaints of dizziness and truncal ataxia. Magnetic resonance image showed a cerebellar tumor with multiple cavernomas and two lesions that were suspected to be meningiomas. The cerebellar tumor was surgically removed. According to pathological examination, the tumor was a high-grade glioma that was positive for methylated O-6-methylguanine-DNA methyltransferase promoter. In the past, he had received radiotherapy at the age of 5, after which he was operated for desmoplastic medulloblastoma in his right cerebellar hemisphere. Seven years after the initial therapy, cavernoma-induced intracerebral hemorrhage of the right temporal lobe was noted. To our knowledge, this is the first case of radiation-induced double intracranial tumors accompanied by symptomatic cavernoma.
- Subjects :
- Adult
Cerebellar Neoplasms genetics
Cerebellar Neoplasms pathology
DNA Methylation
DNA Modification Methylases genetics
DNA Repair Enzymes genetics
Glioma genetics
Glioma pathology
Hemangioma, Cavernous, Central Nervous System genetics
Hemangioma, Cavernous, Central Nervous System pathology
Humans
Male
Medulloblastoma radiotherapy
Meningeal Neoplasms etiology
Meningeal Neoplasms genetics
Meningeal Neoplasms pathology
Meningioma genetics
Neoplasms, Radiation-Induced genetics
Polymerase Chain Reaction
Promoter Regions, Genetic genetics
Tumor Suppressor Proteins genetics
Cerebellar Neoplasms etiology
Glioma etiology
Hemangioma, Cavernous, Central Nervous System etiology
Meningioma etiology
Meningioma pathology
Neoplasms, Radiation-Induced pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-7373
- Volume :
- 100
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of neuro-oncology
- Publication Type :
- Academic Journal
- Accession number :
- 20354758
- Full Text :
- https://doi.org/10.1007/s11060-010-0166-0