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Oral administration of acidic xylooligosaccharides prevents the development of atopic dermatitis-like skin lesions in NC/Nga mice.
- Source :
-
Journal of nutritional science and vitaminology [J Nutr Sci Vitaminol (Tokyo)] 2010; Vol. 56 (1), pp. 54-9. - Publication Year :
- 2010
-
Abstract
- We examined whether two types of xylooligosaccharides (neutral or acidic xylooligosaccharides) derived from hardwood kraft pulp ameliorate the development of atopic dermatitis (AD)-like skin lesions induced by repeated application of picryl chloride (PiCl) in NC/Nga mice. Oral administration of acidic xylooligosaccharides at a daily dose of 100 mg/kg significantly prevented the development of AD-like skin lesions. Serum histamine level was significantly suppressed, but serum total IgE level was not significantly suppressed. Moreover, the secretion of inflammatory cytokine IL-12 from splenic lymphocytes was significantly suppressed. On the other hand, neutral xylooligosaccharides showed no significant preventive effect on the development of AD-like symptoms. These results suggest that oral administration of acidic xylooligosaccharides may be effective in preventing the development of AD-like skin disease and one of the mechanisms is the suppressive effect on IL-12.
- Subjects :
- Acids
Administration, Oral
Animals
Cells, Cultured
Dermatitis, Atopic immunology
Dermatitis, Atopic pathology
Histamine blood
Immunoglobulin E blood
Interleukin-12 metabolism
Lymphocytes drug effects
Male
Mice
Mice, Inbred Strains
Oligosaccharides administration & dosage
Oligosaccharides pharmacology
Plant Extracts administration & dosage
Plant Extracts pharmacology
Skin immunology
Skin pathology
Spleen cytology
Dermatitis, Atopic prevention & control
Magnoliopsida
Oligosaccharides therapeutic use
Phytotherapy
Plant Extracts therapeutic use
Skin drug effects
Wood
Subjects
Details
- Language :
- English
- ISSN :
- 1881-7742
- Volume :
- 56
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of nutritional science and vitaminology
- Publication Type :
- Academic Journal
- Accession number :
- 20354347
- Full Text :
- https://doi.org/10.3177/jnsv.56.54