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Changes in salivary prostaglandin levels during menstrual migraine with associated dysmenorrhea.
- Source :
-
Headache [Headache] 2010 May; Vol. 50 (5), pp. 844-51. Date of Electronic Publication: 2010 Mar 26. - Publication Year :
- 2010
-
Abstract
- Objective: To measure prostaglandin levels in the saliva of individuals during menstrual migraine associated with dysmenorrhea (MMaD) and in response to treatment with a single tablet combination of sumatriptan succinate and naproxen sodium.<br />Background: Prostaglandins are thought to play a role in MMaD as elevated serum prostaglandin levels have been reported during attacks of menstrual migraine and are increased in the menstrual fluid of women with dysmenorrhea. While triptans are the primary line of migraine treatment, nonsteriodal anti-inflammatory drugs are the most commonly prescribed therapy for dysmenorrhea symptoms. Data from recent clinical studies have provided evidence that treatment with a single tablet combination of sumatriptan and naproxen sodium is an effective abortive therapy for attacks of MMaD.<br />Methods: Women diagnosed with MMaD were treated with a sumatriptan succinate and naproxen sodium single tablet combination or placebo at time of migraine attack. Saliva samples were collected at time of attack as well as 2 and 4 hours after treatment. PGD(2), PGE(2), PGF(2), PGI(2), and TXA(2) levels were determined by enzyme-linked immunosorbent assay.<br />Results: Elevated levels of PGD(2), PGF(2), and TXA(2) at 2 and 4 hours and PGE(2) at 4 hours were found in saliva obtained from placebo subjects when compared with onset of attack levels. However, in subjects treated with a single tablet combination of sumatriptan and naproxen sodium, the levels of PGD(2), PGF(2), and PGE(2) were not elevated at either time point while TXA(2) levels were still elevated at 4 hours.<br />Conclusions: Data from this pilot study provide evidence that saliva levels of several prostaglandins increase during attacks of MMaD and that treatment with a single tablet combination of sumatriptan and naproxen sodium prevents elevation of prostaglandin levels.
- Subjects :
- Adult
Double-Blind Method
Dysmenorrhea complications
Female
Humans
Middle Aged
Migraine Disorders etiology
Premenstrual Syndrome complications
Premenstrual Syndrome drug therapy
Premenstrual Syndrome metabolism
Prostaglandins biosynthesis
Serotonin Receptor Agonists administration & dosage
Treatment Outcome
Young Adult
Dysmenorrhea drug therapy
Dysmenorrhea metabolism
Migraine Disorders drug therapy
Migraine Disorders metabolism
Naproxen administration & dosage
Prostaglandins metabolism
Saliva metabolism
Sumatriptan administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1526-4610
- Volume :
- 50
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Headache
- Publication Type :
- Academic Journal
- Accession number :
- 20353434
- Full Text :
- https://doi.org/10.1111/j.1526-4610.2010.01657.x