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Hypomethylating agent induction therapy followed by hematopoietic cell transplantation is feasible in patients with myelodysplastic syndromes.
- Source :
-
Clinical advances in hematology & oncology : H&O [Clin Adv Hematol Oncol] 2010 Jan; Vol. 8 (1), pp. 40-6. - Publication Year :
- 2010
-
Abstract
- Disease remission in patients with myelodysplastic syndromes can be achieved with azanucleosides, which act as pyrimidine analogs and hypomethylating agents. However, despite treatment with azanucleoside induction, patients with myelodysplastic syndromes nearly always relapse. Allogeneic hematopoietic cell transplantation (HCT) can be curative, but it is risky. Given that azanucleosides affect human leukocyte antigen expression and lymphocyte reactivity, we conducted a retrospective study to define the impact of pre-HCT azanucleoside therapy on post-HCT donor chimerism. Patients receiving azanucleoside induction therapy achieved rapid and high levels of donor chimerism post-transplant. Lineage analysis also found rapid donor chimerism of lymphocyte and granulocyte subsets. These data indicate the feasibility of pretransplant azanucleoside therapy in patients who subsequently receive an HCT.
- Subjects :
- Azacitidine analogs & derivatives
Azacitidine therapeutic use
Decitabine
Enzyme Inhibitors therapeutic use
Female
HLA Antigens immunology
Hematopoietic Stem Cell Transplantation
Histocompatibility Testing
Humans
Male
Myelodysplastic Syndromes immunology
Myelodysplastic Syndromes mortality
Neoadjuvant Therapy methods
Recurrence
Retrospective Studies
Survival Rate
Transplantation Chimera
Myelodysplastic Syndromes drug therapy
Myelodysplastic Syndromes surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1543-0790
- Volume :
- 8
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Clinical advances in hematology & oncology : H&O
- Publication Type :
- Academic Journal
- Accession number :
- 20351682