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[A man in his sixties with myocardial infarction, stent thrombosis and haemorrhage].
- Source :
-
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke [Tidsskr Nor Laegeforen] 2010 Mar 25; Vol. 130 (6), pp. 613-5. - Publication Year :
- 2010
-
Abstract
- A man in his sixties had acute ST-elevation myocardial infarction (treated with PCI [percutaneous coronary intervention] and antithrombotic medication) complicated by recurrent stent thrombosis. Excessive haematuria and discovery of a urinary bladder cancer complicated the antithrombotic treatment. Due to recurrent stent thrombosis the patient underwent a total of four PCIs and received the glycoprotein IIb/IIIa-inhibitor abciximab on two occasions. After the last administration of abciximab he developed excessive bleeding within an hour; a blood sample revealed severe thrombocytopenia (2 x 10(9)/l). Severe thrombocytopenia is a rare, but well-known complication to glycoprotein IIb/IIIa-inhibitor treatment and is most often seen after readministration of abciximab. The problem of recurrent coronary stent thrombosis was solved by aorto-coronary bypass surgery, which should always be considered in patients with recurrent stent thrombosis and complications to anti-thrombotic treatment. When bleeding occurs in connection with abciximab treatment, especially within the first month after previous treatment, severe thrombocytopenia should always be considered as a possible cause. Abciximab should be avoided in patients with a history of severe abciximab-related thrombocytopenia.
- Subjects :
- Abciximab
Angioplasty, Balloon
Antibodies, Monoclonal adverse effects
Antibodies, Monoclonal therapeutic use
Anticoagulants therapeutic use
Coronary Artery Bypass
Coronary Disease diagnosis
Coronary Disease therapy
Coronary Thrombosis diagnosis
Coronary Thrombosis etiology
Hematuria complications
Humans
Immunoglobulin Fab Fragments adverse effects
Immunoglobulin Fab Fragments therapeutic use
Male
Middle Aged
Myocardial Infarction diagnosis
Myocardial Infarction drug therapy
Recurrence
Thrombocytopenia chemically induced
Urinary Bladder Neoplasms complications
Anticoagulants adverse effects
Coronary Thrombosis drug therapy
Hemorrhage chemically induced
Myocardial Infarction therapy
Stents adverse effects
Subjects
Details
- Language :
- Norwegian
- ISSN :
- 0807-7096
- Volume :
- 130
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke
- Publication Type :
- Academic Journal
- Accession number :
- 20349007
- Full Text :
- https://doi.org/10.4045/tidsskr.09.0320