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Atypical/Nor98 scrapie in the Basque Country: a case report of eight outbreaks.
- Source :
-
BMC veterinary research [BMC Vet Res] 2010 Mar 26; Vol. 6, pp. 17. Date of Electronic Publication: 2010 Mar 26. - Publication Year :
- 2010
-
Abstract
- Background: Since 2002, an active surveillance program for transmissible spongiform encephalopathy in small ruminants in European Union countries allowed identification of a considerable number of atypical cases with similarities to the previously identified atypical scrapie cases termed Nor98.<br />Case Presentation: Here we report molecular and neuropathological features of eight atypical/Nor98 scrapie cases detected between 2002 and 2009. Significant features of the affected sheep included: their relatively high ages (mean age 7.9 years, range between 4.3 and 12.8), their breed (all Latxa) and their PRNP genotypes (AFRQ/ALRQ, ALRR/ALRQ, AFRQ/AFRQ, AFRQ/AHQ, ALRQ/ALRH, ALRQ/ALRQ). All the sheep were confirmed as atypical scrapie by immunohistochemistry and immunoblotting. Two cases presented more PrP immunolabelling in cerebral cortex than in cerebellum.<br />Conclusions: This work indicates that atypical scrapie constitutes the most common small ruminant transmissible spongiform encephalopathy form in Latxa sheep in the Spanish Basque Country. Moreover, a new genotype (ALRQ/ALRH) was found associated to atypical scrapie.
Details
- Language :
- English
- ISSN :
- 1746-6148
- Volume :
- 6
- Database :
- MEDLINE
- Journal :
- BMC veterinary research
- Publication Type :
- Academic Journal
- Accession number :
- 20346155
- Full Text :
- https://doi.org/10.1186/1746-6148-6-17