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Pre-synaptic glutamate-induced activation of DA release in the striatum after partial nigral lesion.
- Source :
-
Journal of neurochemistry [J Neurochem] 2010 Jun; Vol. 113 (6), pp. 1459-70. Date of Electronic Publication: 2010 Mar 12. - Publication Year :
- 2010
-
Abstract
- The present experiments aimed at understanding the functional link between dopamine (DA) and glutamate (GLU) during the compensatory processes taking place after partial DA denervation. Lesion of the lateral part of substantia nigra in rats using 6-hydroxydopamine resulted in DA denervation of the lateral region of the ipsilateral caudate/putamen complex (CPc) whereas the medial CPc was spared. In vivo voltammetry revealed a large increase of extracellular dopamine (DA(ext)) in the medial CPc both ipsilateral and contralateral to the lesion. In addition, in vivo microdialysis and HPLC-ED revealed a concomitant increase of extracellular glutamate (GLU(ext)) in the ipsilateral medial CPc. Post-lesion chronic treatment with the putative neuroprotectors amantadine, memantine, and riluzole counteracted the tonic increases of DA(ext) and GLU(ext), revealing a possible role of GLU neurotransmission in the DA over-expression. Finally, acute low doses of GBR12909 had no effect on the DA(ext) in sham- operated animals, but dramatically increased DA(ext) in lesioned animals. The data suggest that a partial unilateral nigral lesion induces a bilateral increase of DA turn-over in the non-denervated striata through GLU afferences to the DA terminals.
- Subjects :
- 3,4-Dihydroxyphenylacetic Acid metabolism
Amino Acids metabolism
Animals
Brain Injuries chemically induced
Chromatography, High Pressure Liquid methods
Dopamine Agents pharmacology
Electrochemotherapy methods
Homovanillic Acid metabolism
Male
Microdialysis methods
Oxidopamine
Presynaptic Terminals metabolism
Rats
Rats, Wistar
Brain Injuries pathology
Corpus Striatum drug effects
Dopamine metabolism
Glutamic Acid pharmacology
Presynaptic Terminals drug effects
Substantia Nigra
Subjects
Details
- Language :
- English
- ISSN :
- 1471-4159
- Volume :
- 113
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of neurochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 20345766
- Full Text :
- https://doi.org/10.1111/j.1471-4159.2010.06682.x