Back to Search
Start Over
Effects of raloxifene treatment on the structural geometry of the proximal femur in Japanese women with osteoporosis.
- Source :
-
Journal of bone and mineral metabolism [J Bone Miner Metab] 2010 Sep; Vol. 28 (5), pp. 561-7. Date of Electronic Publication: 2010 Mar 24. - Publication Year :
- 2010
-
Abstract
- The purpose of this study was to clarify the effects of 2-year treatment with raloxifene on the proximal femoral geometry among Japanese patients with osteoporosis by hip structure analysis. One hundred ninety-eight community-dwelling postmenopausal women with osteoporosis were enrolled. The structural variables were areal bone mineral density (BMD), cross-sectional area (CSA), section modulus (index of resistance to bending forces), and buckling ratio (index of cortical instability). BMD, CSA, and section modulus at the narrow neck significantly increased by 1.27, 2.67, and 3.90% at 2 years, respectively. BMD, CSA, and section modulus at the intertrochanter significantly increased by 2.55, 4.49, and 6.60% at study termination, respectively. The buckling ratio at the intertrochanter decreased by 2.36% at 1 year, but differences at 2 years became non-significant. Parameters at the shaft were qualitatively similar to those of the narrow neck and intertrochanter. The percent change of the section modulus was significantly higher than that of BMD at 2 years in all three regions. The percent changes of the section modulus is strongly correlated with the percent changes of BMD and CSA, and negative correlated with the percent changes of buckling ratio in all regions. In conclusion, Japanese osteoporotic women on raloxifene therapy have significant improvements of both BMD and geometry in the proximal femur.
- Subjects :
- Absorptiometry, Photon
Asian People
Bone Density drug effects
Female
Hip anatomy & histology
Hip diagnostic imaging
Humans
Postmenopause
Bone Density Conservation Agents pharmacology
Bone Density Conservation Agents therapeutic use
Femur anatomy & histology
Femur diagnostic imaging
Femur drug effects
Osteoporosis diagnostic imaging
Osteoporosis drug therapy
Raloxifene Hydrochloride pharmacology
Raloxifene Hydrochloride therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1435-5604
- Volume :
- 28
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of bone and mineral metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 20333418
- Full Text :
- https://doi.org/10.1007/s00774-010-0164-5