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Chemoenzymatic dynamic kinetic resolution of axially chiral allenes.
- Source :
-
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2010 Apr 19; Vol. 16 (15), pp. 4447-51. Date of Electronic Publication: 2010 Mar 22. - Publication Year :
- 2010
-
Abstract
- At the palladium: Dimeric palladium bromide complexes bearing monodentate N-heterocyclic carbene ligands have been identified as efficient catalysts for the chemoselective racemization of axially chiral allenyl alcohols. In combination with porcine pancreatic lipase as biocatalyst, a dynamic kinetic resolution has been developed, giving access to optically active allenes in good yield and high enantiomeric purity (see scheme).<br /> (Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Details
- Language :
- English
- ISSN :
- 1521-3765
- Volume :
- 16
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Chemistry (Weinheim an der Bergstrasse, Germany)
- Publication Type :
- Academic Journal
- Accession number :
- 20309981
- Full Text :
- https://doi.org/10.1002/chem.201000301