Chemoenzymatic dynamic kinetic resolution of axially chiral allenes.

Authors :: Deska J
del Pozo Ochoa C
Bäckvall JE
Source :: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2010 Apr 19; Vol. 16 (15), pp. 4447-51. Date of Electronic Publication: 2010 Mar 22.
Publication Year :: 2010
Abstract: At the palladium: Dimeric palladium bromide complexes bearing monodentate N-heterocyclic carbene ligands have been identified as efficient catalysts for the chemoselective racemization of axially chiral allenyl alcohols. In combination with porcine pancreatic lipase as biocatalyst, a dynamic kinetic resolution has been developed, giving access to optically active allenes in good yield and high enantiomeric purity (see scheme).<br /> (Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)