Comparison of salivary cortisol and calculated free plasma cortisol during low-dose ACTH test in healthy subjects.

Authors :: Kerlik J
Penesova A
Vlcek M
Imrich R
Vogeser M
Radikova Z
Source :: Clinical biochemistry [Clin Biochem] 2010 Jun; Vol. 43 (9), pp. 764-7. Date of Electronic Publication: 2010 Mar 19.
Publication Year :: 2010
Abstract: Objectives: To compare free plasma cortisol (FPC) with salivary and calculated cortisol.<br />Design and Methods: FPC, salivary cortisol, free cortisol index (FCI), albumin-derived free cortisol index (FCIalb), Coolen's and Dorin's cortisol were assayed during repeated low-dose ACTH test in healthy women.<br />Results: FPC significantly correlated with its surrogates, the most with FCIalb and salivary cortisol. FPC and salivary cortisol showed the highest method agreement.<br />Conclusions: FCIalb and salivary cortisol are preferred surrogates of FPC.<br /> (2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.)

Subjects :: Adrenocorticotropic Hormone administration & dosage
Adult
Female
Follicular Phase
Humans
Hydrocortisone blood
Adrenocorticotropic Hormone pharmacology
Hydrocortisone analysis
Saliva chemistry

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