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New sequence variants in HLA class II/III region associated with susceptibility to knee osteoarthritis identified by genome-wide association study.
- Source :
-
PloS one [PLoS One] 2010 Mar 18; Vol. 5 (3), pp. e9723. Date of Electronic Publication: 2010 Mar 18. - Publication Year :
- 2010
-
Abstract
- Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through a genome-wide association study and a replication using a total of approximately 4,800 Japanese subjects, we identified two single nucleotide polymorphisms (SNPs) (rs7775228 and rs10947262) associated with susceptibility to knee OA. The two SNPs were in a region containing HLA class II/III genes and their association reached genome-wide significance (combined P = 2.43x10(-8) for rs7775228 and 6.73x10(-8) for rs10947262). Our results suggest that immunologic mechanism is implicated in the etiology of OA.
- Subjects :
- Aged
Case-Control Studies
Female
Humans
Japan
Linkage Disequilibrium
Male
Middle Aged
Principal Component Analysis
Genetic Predisposition to Disease
Genome-Wide Association Study
Histocompatibility Antigens genetics
Histocompatibility Antigens Class II genetics
Osteoarthritis, Knee genetics
Polymorphism, Single Nucleotide
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 5
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 20305777
- Full Text :
- https://doi.org/10.1371/journal.pone.0009723