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Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease.
- Source :
-
Nature neuroscience [Nat Neurosci] 2010 Apr; Vol. 13 (4), pp. 411-3. Date of Electronic Publication: 2010 Mar 21. - Publication Year :
- 2010
-
Abstract
- Microglia, the immune cells of the brain, can have a beneficial effect in Alzheimer's disease by phagocytosing amyloid-beta. Two-photon in vivo imaging of neuron loss in the intact brain of living Alzheimer's disease mice revealed an involvement of microglia in neuron elimination, indicated by locally increased number and migration velocity of microglia around lost neurons. Knockout of the microglial chemokine receptor Cx3cr1, which is critical in neuron-microglia communication, prevented neuron loss.
- Subjects :
- Alzheimer Disease genetics
Alzheimer Disease pathology
Animals
CX3C Chemokine Receptor 1
Cell Communication genetics
Cell Count
Disease Models, Animal
Gene Knock-In Techniques
Mice
Mice, Knockout
Mice, Transgenic
Microglia pathology
Neurons pathology
Receptors, Chemokine genetics
Alzheimer Disease metabolism
Microglia metabolism
Neurons metabolism
Receptors, Chemokine deficiency
Subjects
Details
- Language :
- English
- ISSN :
- 1546-1726
- Volume :
- 13
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Nature neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 20305648
- Full Text :
- https://doi.org/10.1038/nn.2511