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Glucose flux in controlled hyperglycaemia before and after oral glucose ingestion in men with mild type 2 diabetes.
- Source :
-
Diabetes & metabolism [Diabetes Metab] 2010 Jun; Vol. 36 (3), pp. 234-9. Date of Electronic Publication: 2010 Mar 19. - Publication Year :
- 2010
-
Abstract
- Aims: This study aimed to determine how insufficiently suppressed endogenous glucose production vs. reduced peripheral glucose uptake contribute to postprandial hyperglycaemia in type 2 diabetes (T2D).<br />Methods: Eight men with T2D (age: 52+/-7 years; BMI: 26.6+/-2.3 kg/m(2); fasting glycaemia: 7.1+/-1.5 mmol/L) were compared with eight non-diabetic controls (age: 51+/-5 years; BMI: 24.6+/-2.9 kg/m(2); fasting glycaemia: 4.9+/-0.4 mmol/L). Their glucose turnover rates and hepatic glucose cycles were measured by monitoring [2H7]glucose infusion, with m+7 and m+6 enrichment, 3 h before and 4 h after the ingestion of [6,6-2H2]-labelled glucose, while maintaining glycaemia at 10 mmol/L using the pancreatic clamp technique.<br />Results: Of the 700 mg/kg oral glucose load, 71% appeared in the systemic circulation of the T2D patients vs. 63% in the controls (NS). Endogenous glucose production and hepatic glucose cycles did not differ from normal either before or after oral glucose ingestion, while peripheral glucose uptake was reduced by 40% in the T2D group both before (P<0.01) and after (P<0.05) ingestion of oral glucose.<br />Conclusion: When T2D patients were compared with non-diabetic subjects with similarly controlled levels of hyperglycaemia after oral glucose ingestion, they essentially differed only in peripheral glucose uptake, whereas endogenous glucose production was apparently unaltered.<br /> (Copyright 2010 Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Blood Glucose metabolism
C-Peptide blood
Diabetes Mellitus, Type 2 blood
Glucagon blood
Glucose Tolerance Test
Humans
Hyperglycemia blood
Insulin blood
Male
Middle Aged
Statistics, Nonparametric
Diabetes Mellitus, Type 2 metabolism
Glucose administration & dosage
Glucose metabolism
Hyperglycemia metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1878-1780
- Volume :
- 36
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Diabetes & metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 20303815
- Full Text :
- https://doi.org/10.1016/j.diabet.2010.01.007