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[Role of neuraminidase inhibitors for the treatment of influenza A virus infections].
- Source :
-
Pathologie-biologie [Pathol Biol (Paris)] 2010 Apr; Vol. 58 (2), pp. e69-78. Date of Electronic Publication: 2010 Mar 19. - Publication Year :
- 2010
-
Abstract
- Oseltamivir and zanamivir are two neuraminidase inhibitors (NAIs) active on A and B influenza viruses. These analogues have been developed from the structure of sialic acid, the neuraminidase (NA) substrate. Resistance to NAIs have been detected. They are mainly associated to mutations located on the NA gene. The use of these antiviral drugs remains low in the context of seasonal flu, even the duration of symptoms can be reduced of one day if an antiviral treatment is started within 48 hours after disease onset. NAIs also present a significant effect when used in postexposition prophylaxis. Resistance, mainly to oseltamivir, have been detected but remained rare until the spontaneous emergence in 2007-2008 winter of a seasonal A(H1N1) variant resistant to this drug. NAIs are also interesting for the treatment of severe flu infections, specially those associated to A(H5N1). Finally, because of the pandemic A(H1N1)2009 virus, NAIs use has largely increased for prophylactic and therapeutic treatment of severe and non severe infections. This large use may be associated to an increased risk of selection of resistant viruses. Up to now, this phenomenon remains fortunately limited but has to be closely monitored.<br /> (Copyright 2010 Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Adult
Antiviral Agents administration & dosage
Antiviral Agents chemistry
Antiviral Agents pharmacology
Child
Clinical Trials as Topic
Disease Outbreaks
Double-Blind Method
Drug Resistance, Viral genetics
Drug Therapy, Combination
Female
Humans
Immunocompromised Host
Influenza A virus enzymology
Influenza A virus genetics
Influenza, Human epidemiology
Influenza, Human prevention & control
Male
Models, Molecular
Molecular Structure
Mutation, Missense
Neuraminidase chemistry
Neuraminidase genetics
Oseltamivir administration & dosage
Oseltamivir chemistry
Oseltamivir pharmacology
Point Mutation
Pregnancy
Pregnancy Complications, Infectious drug therapy
Pregnancy Complications, Infectious virology
Protein Conformation
Viral Proteins chemistry
Viral Proteins genetics
Zanamivir administration & dosage
Zanamivir chemistry
Zanamivir pharmacology
Antiviral Agents therapeutic use
Influenza A virus drug effects
Influenza, Human drug therapy
Neuraminidase antagonists & inhibitors
Oseltamivir therapeutic use
Viral Proteins antagonists & inhibitors
Zanamivir therapeutic use
Subjects
Details
- Language :
- French
- ISSN :
- 1768-3114
- Volume :
- 58
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Pathologie-biologie
- Publication Type :
- Academic Journal
- Accession number :
- 20303677
- Full Text :
- https://doi.org/10.1016/j.patbio.2010.01.011