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Heterocyclic fused pyridone carboxylic acid M(1) positive allosteric modulators.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Apr 15; Vol. 20 (8), pp. 2533-7. Date of Electronic Publication: 2010 Mar 03. - Publication Year :
- 2010
-
Abstract
- The phenyl ring in a series of quinolone carboxylic acid M(1) positive allosteric modulators was replaced with a variety of heterocycles in order to reduce protein plasma binding and enhance CNS exposure.<br /> (Copyright 2010. Published by Elsevier Ltd.)
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 20
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 20303264
- Full Text :
- https://doi.org/10.1016/j.bmcl.2010.02.096