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Egr-1-A Ca(2+)-regulated transcription factor.
- Source :
-
Cell calcium [Cell Calcium] 2010 May; Vol. 47 (5), pp. 397-403. Date of Electronic Publication: 2010 Mar 29. - Publication Year :
- 2010
-
Abstract
- The biosynthesis of the zinc finger transcription factor Egr-1 is stimulated by many extracellular signaling molecules including hormones, neurotransmitters, growth and differentiation factors. The Egr-1 gene represents a convergence point for many intracellular signaling cascades. An increase of the intracellular Ca(2+) concentration, by activating ionotropic or Galpha(q/11)-coupled receptors or voltage-gated L-type Ca(2+) channels, is often the prerequisite for enhanced Egr-1 gene transcription. This increase has been observed following stimulation with extracellular signaling molecules including ATP, glutamate, thrombin, carbachol, gonadotropin-releasing hormone, or glucose. Egr-1 is thus a Ca(2+) regulated transcription factor - similar to CREB, NFAT, NF-kappaB and others. This review also discusses the importance of the cytoplasmic and nuclear Ca(2+) concentration in transcriptional regulation of the Egr-1 gene.<br /> (2010 Elsevier Ltd. All rights reserved.)
- Subjects :
- Calcium Channels, L-Type metabolism
Calcium Signaling
Early Growth Response Protein 1 biosynthesis
Early Growth Response Protein 1 genetics
Gene Expression Regulation
Humans
NFATC Transcription Factors metabolism
Receptors, G-Protein-Coupled metabolism
Calcium metabolism
Early Growth Response Protein 1 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1532-1991
- Volume :
- 47
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Cell calcium
- Publication Type :
- Academic Journal
- Accession number :
- 20303171
- Full Text :
- https://doi.org/10.1016/j.ceca.2010.02.005