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Synthetic UDP-furanoses inhibit the growth of the parasite Leishmania.
- Source :
-
Carbohydrate research [Carbohydr Res] 2010 Jul 02; Vol. 345 (10), pp. 1299-305. Date of Electronic Publication: 2010 Feb 24. - Publication Year :
- 2010
-
Abstract
- The chemical synthesis of UDP-6-NHAc-6-deoxy-Galf was performed and it led to the isolation of both pure anomers. They were then evaluated together with the previously prepared UDP-furanoses for their anti-parasitic properties against Leishmania donovani promastigotes, one of the agents responsible for visceral leishmaniasis. Amongst them, the unnatural 1,2-trans UDP-6-NHAc-Galf demonstrated a high potency in inhibiting the growth of the parasite.<br /> (Copyright 2010 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1873-426X
- Volume :
- 345
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Carbohydrate research
- Publication Type :
- Academic Journal
- Accession number :
- 20303072
- Full Text :
- https://doi.org/10.1016/j.carres.2010.02.020