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Synthetic UDP-furanoses inhibit the growth of the parasite Leishmania.

Authors :
Dureau R
Robert-Gangneux F
Gangneux JP
Nugier-Chauvin C
Legentil L
Daniellou R
Ferrières V
Source :
Carbohydrate research [Carbohydr Res] 2010 Jul 02; Vol. 345 (10), pp. 1299-305. Date of Electronic Publication: 2010 Feb 24.
Publication Year :
2010

Abstract

The chemical synthesis of UDP-6-NHAc-6-deoxy-Galf was performed and it led to the isolation of both pure anomers. They were then evaluated together with the previously prepared UDP-furanoses for their anti-parasitic properties against Leishmania donovani promastigotes, one of the agents responsible for visceral leishmaniasis. Amongst them, the unnatural 1,2-trans UDP-6-NHAc-Galf demonstrated a high potency in inhibiting the growth of the parasite.<br /> (Copyright 2010 Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1873-426X
Volume :
345
Issue :
10
Database :
MEDLINE
Journal :
Carbohydrate research
Publication Type :
Academic Journal
Accession number :
20303072
Full Text :
https://doi.org/10.1016/j.carres.2010.02.020