Hyaluronan induces migration of multidrug-resistant lymphoma cell lines in vitro through Tiam1 activation by a PI3K-dependent mechanism.

Authors :: Cordo-Russo RI
Alaniz LD
Saccodossi N
Lompardía S
Blanco G
Alvarez E
García MG
Hajos SE
Source :: Leukemia research [Leuk Res] 2010 Nov; Vol. 34 (11), pp. 1525-32. Date of Electronic Publication: 2010 Mar 17.
Publication Year :: 2010
Abstract: Hyaluronan (HA) modulates multidrug resistance (MDR) as well as cell migration. Tiam1 is involved in cytoskeleton reorganization during tumor invasion. In this report we show the relationship among HA, Tiam1, migration and MDR in murine lymphoma cell lines. We observed that MDR cells presented higher migratory capacity towards HA in vitro as well as higher constitutive active Tiam1 expression than the sensitive cell line. Besides, HA treatment induced migration towards HA of MDR cell lines through Tiam1 activation by a PI3K-dependent mechanism, showing that disruption of HA signaling would be useful in treatment of MDR hematological malignancies.<br /> (Copyright © 2010 Elsevier Ltd. All rights reserved.)

Subjects :: Animals
Cell Line, Tumor
Lymphoma pathology
Mice
Signal Transduction
T-Lymphoma Invasion and Metastasis-inducing Protein 1
Cell Movement drug effects
Drug Resistance, Multiple
Guanine Nucleotide Exchange Factors metabolism
Hyaluronic Acid pharmacology
Lymphoma drug therapy
Phosphatidylinositol 3-Kinases metabolism

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