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Farnesyl diphosphate synthase attenuates paclitaxel-induced apoptotic cell death in human glioblastoma U87MG cells.
- Source :
-
Neuroscience letters [Neurosci Lett] 2010 Apr 26; Vol. 474 (2), pp. 115-20. Date of Electronic Publication: 2010 Mar 15. - Publication Year :
- 2010
-
Abstract
- Increased expression of farnesyl diphosphate synthase (FPPS) by stable transfection appeared to attenuate paclitaxel-induced apoptotic cell death in human glioblastoma U87MG cells. The present results suggest that the apoptotic functions of p53 and c-Jun N-terminal kinase (JNK) are affected by FPPS. Farnesyl diphosphate, a catalytic product of FPPS, also attenuated mentioned paclitaxel-induced apoptotic cell death. As expected, the FPPS inhibitor, pamidronate, enhanced paclitaxel-induced apoptotic cell death. The present results suggest that FPPS plays an important role in apoptotic cell death of cancer cells by blocking the JNK signaling cascade and activating mevalonate metabolism in paclitaxel-treated glioblastoma cells.<br /> (Copyright 2010 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Cell Line, Tumor
Cell Survival drug effects
Diphosphonates pharmacology
Drug Synergism
Flow Cytometry methods
Geranyltranstransferase genetics
Glioblastoma pathology
Glioblastoma physiopathology
Humans
JNK Mitogen-Activated Protein Kinases metabolism
Mevalonic Acid pharmacology
Pamidronate
Polyisoprenyl Phosphates metabolism
Sesquiterpenes metabolism
Signal Transduction drug effects
Time Factors
Tumor Suppressor Protein p53 metabolism
Antineoplastic Agents, Phytogenic pharmacology
Apoptosis drug effects
Geranyltranstransferase metabolism
Paclitaxel pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7972
- Volume :
- 474
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Neuroscience letters
- Publication Type :
- Academic Journal
- Accession number :
- 20298756
- Full Text :
- https://doi.org/10.1016/j.neulet.2010.03.021