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Apomorphine is a potent inhibitor of type 2A protein phosphatase in rat brain.

Authors :
Kawai S
Source :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1991 Apr 30; Vol. 176 (2), pp. 737-40.
Publication Year :
1991

Abstract

Effects of five kinds of dopamine agonists on the activity of type 2A protein phosphatase in rat brain were studied. Apomorphine and SKF-38393 reduced the enzyme activity considerably and their effects were further enhanced in the presence of 10 microM Mn2+. Also, 6,7-ADTN slightly inhibited the activity. The present results suggest that type 2A protein phosphatase in the brain is possibly involved in dopamine mediated protein phosphorylation functions.

Subjects

Subjects :
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine pharmacology
Animals
Brain drug effects
Phosphorylation
Rats
Rats, Inbred Strains
Apomorphine pharmacology
Brain enzymology
Phosphoproteins antagonists & inhibitors
Proteins pharmacology

Details

Language :
English
ISSN :
0006-291X
Volume :
176
Issue :
2
Database :
MEDLINE
Journal :
Biochemical and biophysical research communications
Publication Type :
Academic Journal
Accession number :
2025287
Full Text :
https://doi.org/10.1016/s0006-291x(05)80246-3
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