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Synthetic studies toward the mannopeptimycins: synthesis of orthogonally protected beta-hydroxyenduracididines.
- Source :
-
Organic letters [Org Lett] 2010 Apr 16; Vol. 12 (8), pp. 1680-3. - Publication Year :
- 2010
-
Abstract
- The asymmetric synthesis of the nonproteinogenic amino acids (2S,3S,4'S)-beta-hydroxyenduracididine 3 and (2R,3S,4'S)-beta-hydroxyenduracididine 4 in orthogonally protected form in 15 total steps from Garner's aldehyde is reported. The former and N-glycosylated form of the latter are found in the glycopeptide antibiotic mannopeptimycin.
- Subjects :
- Anti-Bacterial Agents pharmacology
Enterococcus faecium drug effects
Glycopeptides pharmacology
Methicillin-Resistant Staphylococcus aureus drug effects
Microbial Sensitivity Tests
Anti-Bacterial Agents chemical synthesis
Anti-Bacterial Agents chemistry
Glycopeptides chemical synthesis
Glycopeptides chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 12
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 20232818
- Full Text :
- https://doi.org/10.1021/ol100219a