Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).

Authors :: Franke A
Balschun T
Sina C
Ellinghaus D
Häsler R
Mayr G
Albrecht M
Wittig M
Buchert E
Nikolaus S
Gieger C
Wichmann HE
Sventoraityte J
Kupcinskas L
Onnie CM
Gazouli M
Anagnou NP
Strachan D
McArdle WL
Mathew CG
Rutgeerts P
Vermeire S
Vatn MH
Krawczak M
Rosenstiel P
Karlsen TH
Schreiber S
Source :: Nature genetics [Nat Genet] 2010 Apr; Vol. 42 (4), pp. 292-4. Date of Electronic Publication: 2010 Mar 14.
Publication Year :: 2010
Abstract: We performed a genome-wide association analysis of 1,897,764 SNPs in 1,043 German ulcerative colitis (UC) cases and 1,703 controls. We discovered new associations at chromosome 7q22 (rs7809799) and at chromosome 22q13 in IL17REL (rs5771069) and confirmed these associations in six replication panels (2,539 UC cases and 5,428 controls) from different regions of Europe (overall study sample P(rs7809799) = 8.81 x 10(-11) and P(rs5771069) = 4.21 x 10(-8), respectively).

Subjects :: Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Risk Factors
Chromosomes, Human, Pair 22
Chromosomes, Human, Pair 7
Colitis, Ulcerative genetics
Polymorphism, Single Nucleotide
Receptors, Interleukin-17 genetics

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