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Synthesis, anticancer and antioxidant activities of 7-methoxyisoflavanone and 2,3-diarylchromanones.
- Source :
-
European journal of medicinal chemistry [Eur J Med Chem] 2010 Jun; Vol. 45 (6), pp. 2447-52. Date of Electronic Publication: 2010 Feb 14. - Publication Year :
- 2010
-
Abstract
- A convenient, fast and high yielding method for the preparation of 7-methoxyisoflavanone and 2,3-diarylchromanones has been developed by the condensation of benzyl-2-hydroxy-4-alkoxyphenylketone with arylaldehyde/paraformaldehyde in presence of diethylamine, assisted by microwave activation. All the synthesized compounds were screened for anticancer as well as antioxidant activities. Among the nine compounds, 7-methoxyisoflavanone 7 and diarylchromanone 6c shows potential anticancer activity and diarylchromanone 6b has potential antioxidant activity. Compound 6h possesses anticancer and antioxidant activity at the same concentration.<br /> (Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Antineoplastic Agents chemistry
Antineoplastic Agents toxicity
Apoptosis drug effects
DNA Fragmentation drug effects
Free Radical Scavengers chemistry
Free Radical Scavengers toxicity
Green Chemistry Technology
HL-60 Cells
Humans
Isoflavones chemistry
Isoflavones toxicity
Lipid Peroxidation drug effects
Antineoplastic Agents chemical synthesis
Antineoplastic Agents pharmacology
Free Radical Scavengers chemical synthesis
Free Radical Scavengers pharmacology
Isoflavones chemical synthesis
Isoflavones pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1768-3254
- Volume :
- 45
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- European journal of medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 20227144
- Full Text :
- https://doi.org/10.1016/j.ejmech.2010.02.028